SB202190 CAS NO.152121-30-7

Prouduct Name:SB202190

Chemical Name: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol

M.Wt:331.35

Formula:C₂₀H₁₄N₃OF

appearance:yellow powder

Solubility:Soluble to 100 mM in DMSO

Purity:>99 %

Storage:Store at -20°C

CAS No:152121-30-7

SB 202190 significantly inhibits both basal and anti-Fas antibody-induced MAPKAPK 2 activity in a dose-dependent manner. SB202190 by itself is sufficient to induce cell death in Jurkat and HeLa cells through activation of CPP32-like caspases, which can be blocked by expression of bcl-2. SB202190-induced apoptosis is attenuated by p38β but augmented by p38α. SB 202190 strongly inhibits UVB induced COX-2 protein expression in HaCaT cells, and markedly inhibits UVB induced cox-2 mRNA. SB 202190

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Prouduct Name:SB202190

Chemical Name: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol

M.Wt:331.35

Formula:C₂₀H₁₄N₃OF

appearance:yellow powder

Solubility:Soluble to 100 mM in DMSO

Purity:>99 %

Storage:Store at -20°C

CAS No:152121-30-7

SB 202190 significantly inhibits both basal and anti-Fas antibody-induced MAPKAPK 2 activity in a dose-dependent manner. SB202190 by itself is sufficient to induce cell death in Jurkat and HeLa cells through activation of CPP32-like caspases, which can be blocked by expression of bcl-2. SB202190-induced apoptosis is attenuated by p38β but augmented by p38α. SB 202190 strongly inhibits UVB induced COX-2 protein expression in HaCaT cells, and markedly inhibits UVB induced cox-2 mRNA. SB 202190

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